{"id":325,"date":"2021-04-15T09:28:29","date_gmt":"2021-04-15T07:28:29","guid":{"rendered":"https:\/\/bcamonitor.org\/?p=325"},"modified":"2026-09-22T13:34:49","modified_gmt":"2026-09-22T13:34:49","slug":"urinary-markers-includedi-in-new-eau-nmibc-guidelines-2021","status":"publish","type":"post","link":"https:\/\/bcamonitor.org\/?p=325","title":{"rendered":"Urinary markers included in the NEW EAU NMIBC guidelines 2021"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_padding=&#8221;||4px|||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; min_height=&#8221;280px&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><em>Reviewed by Morgan Roupr\u00eat, Professor at the AP-HP Sorbonne University in the Academic Urology Department of the Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France.<br \/> Prof. Roupr\u00eat is a panel member of the European Guidelines for non-muscle invasive bladder cancer (NMIBC).<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>The 2021 EAU guidelines on non-muscle invasive bladder cancer (NMIBC) allow to use urinary markers as method of surveillance in Ta low grade bladder cancer, in case cystoscopy is not possible or refused by the patient [1].<\/strong><\/p>\n<p>For years, the EAU guidelines recommend regular cystoscopy for the follow-up of NMIBC. However, the follow-up schedules with cystoscopy have weak recommendations as they are not evidence-based.<\/p>\n<p>Urinary markers have the opportunity to aid the current follow-up procedures and to reduce the burden associated with regular cystoscopies. Bladder cancer biomarker tests with a high NPV, high sensitivity and high specificity can predict tumour absence with great accuracy and can easily be implemented in daily clinical practice.<\/p>\n<p>The EAU 2020 guidelines already acknowledged a potential role for diagnostic urinary markers:<\/p>\n<p><em>\u201cA test able to predict absence of tumour will have great utility in daily clinical practice.\u201d<\/em><\/p>\n<p><a href=\"https:\/\/bcamonitor.org\/2020\/12\/14\/eau-guidelines-evolving-towards-an-additional-role-of-biomarkers\/\" target=\"_blank\" rel=\"noopener noreferrer\">Watch the editorial comment by Prof. Dr. Paolo Gontero<\/a> on biomarker statements in the EAU 2020 guidelines.<\/p>\n<p>&nbsp;<\/p>\n<p>In the <strong>new EAU 2021 guidelines<\/strong>, one important statement was added:<\/p>\n<p><em>\u201cIn patients initially diagnosed with Ta G1-2\/low grade (LG) bladder cancer, ultrasound of the bladder or <strong>a urinary marker may be a mode of surveillance in case cystoscopy is not possible or refused by the patient<\/strong>\u201d<\/em> [1]<\/p>\n<p>&nbsp;<\/p>\n<p>This update acknowledges the possibility of introducing an alternative follow-up schedule for patients with TaG1-2\/ LG NMIBC in 2 situations:<\/p>\n<ol>\n<li>When cystoscopy not possible \u2013 Due to the ongoing COVID-19 pandemic, cystoscopies may be cancelled\/delayed due to adapted regulations.<\/li>\n<li>When cystoscopy is refused \u2013 Cystoscopy can cause discomfort and pain. A patient might prefer a non-invasive alternative over cystoscopy.<\/li>\n<\/ol>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Patients should be properly informed on urinary markers for bladder cancer surveillance<\/strong>. This will help to optimise and individualise the follow-up schedule for each patient, so that both physicians and patients are satisfied.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><strong>References<\/strong><\/p>\n<ol>\n<li>Babjuk M, Burger M, Comp\u00e9rat E, et al. EAU guidelines on non-muscle-invasive bladder cancer. Update April 2021. Available at: <span><a href=\"https:\/\/uroweb.org\/guideline\/non-muscle-invasive-bladder-cancer\/\">https:\/\/uroweb.org\/guideline\/non-muscle-invasive-bladder-cancer\/<\/a><\/span><\/li>\n<\/ol>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/bcamonitor.org\/slides-brochure\/&#8221; button_text=&#8221;Download the free slide resource and brochure&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; custom_button=&#8221;on&#8221; button_text_color=&#8221;#ffffff&#8221; button_bg_color=&#8221;#3b8dbf&#8221; button_border_width=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.8.2&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;2px||5px|||&#8221; global_module=&#8221;303&#8243; saved_tabs=&#8221;all&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Reviewed by Morgan Roupr\u00eat, Professor at the AP-HP Sorbonne University in the Academic Urology Department of the Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France. Prof. Roupr\u00eat is a panel member of the European Guidelines for non-muscle invasive bladder cancer (NMIBC). &nbsp; The 2021 EAU guidelines on non-muscle invasive bladder cancer (NMIBC) allow to use urinary markers as method [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":178,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-325","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/posts\/325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=325"}],"version-history":[{"count":1,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/posts\/325\/revisions"}],"predecessor-version":[{"id":386,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/posts\/325\/revisions\/386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=\/wp\/v2\/media\/178"}],"wp:attachment":[{"href":"https:\/\/bcamonitor.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bcamonitor.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}